CD3E Mouse Monoclonal Antibody [Clone ID: MEM-57]

CAT#: SM3017B

CD3E mouse monoclonal antibody, clone MEM-57, Biotin

Conjugation: Unconjugated Biotin FITC



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CNY 3,810.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name MEM-57
Applications FC
Recommend Dilution Flow cytometry (starting point 1/300).
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Human thymocytes and T lymphocytes
Specificity The antibody MEM-57 reacts with gamma-epsilon and delta-epsilon dimers of human CD3 complex, a part of a bigger multisubunit T cell receptor complex (CD3/TCR) expressed on peripheral blood T lymphocytes and mature thymocytes.
Formulation Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Label: Biotin
State: Liquid purified Ig fraction
Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration lot specific
Conjugation Biotin
Storage Condition Store the antibody undiluted at 2 - 8 °C. DO NOT FREEZE!
Gene Name CD3e molecule
Background CD3 complex is crucial in transducing antigen-recognition signals into the cytopasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
Synonyms T3/Leu-4
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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