LOC105369261 Mouse Monoclonal Antibody [Clone ID: MEM-59]

CAT#: SM3023LE

LOC105369261 mouse monoclonal antibody, clone MEM-59, Low Endotoxin



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CNY 3,280.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name MEM-59
Applications IHC, WB
Recommend Dilution Functional application: The antibody MEM-59 activates T lymphocytes and also induces apoptosis in hemopoietic progenitor cells.
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Immunohistochemistry (paraffin sections): Positive tissue: spleen, thymus, tonsil; recommended dilution: 10 μg/ml.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Human T lymphocytes
Specificity The antibody MEM-59 recognizes neuraminidase-sensitive epitope on CD43 (Leukosialin), a 95-135 kDa type I transmembrane glycoprotein (mucin-type) which is involved in lymphocyte activation. CD43 is expressed by platelets and at high levels on the surface of all leukocytes; it is negative on resting B lymphocytes and erythrocytes.
Formulation Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized
State: Low Endotoxin
State: Liquid Ig fraction
Concentration lot specific
Purification Protein-A affinity chromatography
Conjugation Unconjugated
Storage Condition

Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Background CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumour suppressor p53 protein, but in case of p53 and ARF defficiency CD43 promotes tumour proliferation and viability. It appears to be an important modulator of leukocyte functions.
Synonyms Leukocyte sialoglycoprotein, Sialophorin, Galactoglycoprotein, SPN
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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