SLP76 (LCP2) Mouse Monoclonal Antibody [Clone ID: SLP-76/03]

Specifications

Product Data
Clone Name	SLP-76/03
Applications	IHC, WB
Recommend Dilution	Western Blot. Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/ml, Positive tissue: thymus.
Reactivity	Human, Porcine, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	A fusion protein representing amino acids 216-434 of human SLP-76
Specificity	The antibody reacts with SLP76, a 76 kDa cytosolic adaptor protein that is involved in signaling of various hematopoietic cells, such as T cells, mast cells or neutrophils; in B cells, however, it is replaced by SLP65.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Purified by protein-A affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	lymphocyte cytosolic protein 2
Database Link	Entrez Gene 3937 Human UniProt ID Q13094
Background	SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-g. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.
Synonyms	LCP2, Lymphocyte cytosolic protein 2, SLP-76 tyrosine phosphoprotein, SLP76
Reference Data

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