DNA PKcs (PRKDC) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	EMSA, IP, WB
Recommend Dilution	Western Blot: 1/2000. Immunoprecipitation. Gel Super Shift Assays. Immunohistochemistry on paraffin sections: 1:100; this product requires heat mediated treatment of paraffin sections; we recommend the use of antigen unmasking fluid for this purpose; a two hour incubation with SP1136 is recommended.
Reactivity	Hamster, Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Human DNA-PKcs fragment
Specificity	This antibody has a strong reactivity with DNA-PKcs.
Formulation	State: Serum State: Liquid serum containing 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	protein kinase, DNA-activated, catalytic polypeptide
Database Link	Entrez Gene 5591 Human UniProt ID P78527
Background	DNA PK is the key component of the non-homologous end-joining (NHEJ) pathway of DSB repair in mammalian cells. DNA PK consists of a heterodimeric DNA-binding subunit (Ku70/80) and an approximately 465 kDa catalytic subunit (DNA PKcs). DNA PKcs is a serine/threonine protein kinase whose activity is greatly stimulated by its recruitment to DNA breaks by the Ku heterodimer.
Synonyms	DNPK1, p460, HYRC, HYRC1
Reference Data

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