xCT (SLC7A11) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, ICC/IF, IHC, IP, WB
Recommend Dilution	Simple Western: 10 ug/ml, Western Blot: 1:1000, Immunocytochemistry/ Immunofluorescence: 1:100-1:1000, Immunohistochemistry-Paraffin: 5 ug/ml, Immunohistochemistry: 5 u/gml, Immunoprecipitation (Negative), Flow Cytometry: 2-3ug/ml, Dual RNAscope ISH-IHC
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to a region within the N-terminus of the human XCT protein sequence (between residues 1-50).
Formulation	Tris-glycine with 150mM NaCl and 0.05% sodium azide
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	solute carrier family 7 member 11
Database Link	NP_055146 Entrez Gene 26570 MouseEntrez Gene 23657 Human UniProt ID Q9UPY5
Background	Mammalian amino acid transport systems consist of a large variety of transporters. The amino acid transporter, cystine/glutamic acid transporter xCT, for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc. In brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to enter cells.
Synonyms	CCBR1; xCT
Reference Data
Protein Families	Druggable Genome, Transmembrane

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