HIF1AN Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Electron Microscopy, ICC/IF, IHC, IP, WB
Recommend Dilution	Immunohistochemistry: 1:100, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation: 1:10-1:500, Electron Microscopy, Immunohistochemistry-Paraffin: 1:50-1:200, Immunohistochemistry-Frozen: 1:50-1:200, Western Blot: 1:1000-1:5000, Knockdown Validated, Knockout Validated
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A C-terminal region synthetic peptide made to the human FIH protein sequence (between residues 300 and the C-terminus).
Formulation	Tris-citrate/phosphate [pH 7-8] buffer. and 0.1% Sodium Azide
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	hypoxia inducible factor 1 alpha subunit inhibitor
Database Link	NP_060372 Entrez Gene 309434 RatEntrez Gene 55662 Human UniProt ID Q9NWT6
Background	Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration.
Synonyms	FIH1
Reference Data
Protein Families	Druggable Genome

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