ROBO4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	Immunocytochemistry/ Immunofluorescence, Immunohistochemistry: 5 ug/ml, Western Blot: 1:500, Immunohistochemistry-Paraffin: 5 ug/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to a C-terminal region of the human protein (within residues 900-1007). [Swiss-Prot# Q8WZ75]
Formulation	Tris-citrate/phosphate [pH 7-8] and 0.1% sodium azide
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	roundabout guidance receptor 4
Database Link	NP_061928 Entrez Gene 54538 Human UniProt ID Q8WZ75
Background	Roundabouts (ROBO) are cell-surface receptors that mediate repulsive signaling mechanisms at the central nervous system midline. However, ROBOs may also mediate attraction mechanisms in the context of vascular development. ROBO4 is a novel roundabout protein which is restricted in expression to endothelial cells in vitro and sites of angiogenesis in vivo. Because it is not expressed on normal endothelial cells, in vivo, it is a promising tumor endothelial marker.
Synonyms	ECSM4; MRB
Reference Data
Protein Families	Druggable Genome

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