Perilipin 3 (PLIN3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, WB
Recommend Dilution	Western Blot: 2 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:100
Reactivity	Human, Primate, Porcine
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide made to a region within the C-terminus (within residues 350-435) of the human TIP47 protein. [Swiss-Prot# O60664]
Formulation	Tris-glycine, 150mM NaCl and 0.05% sodium azide
Concentration	lot specific
Purification	peptide affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	perilipin 3
Database Link	NP_005808 Entrez Gene 10226 Human UniProt ID O60664
Background	TIP47 has been described as cargo protein involved in the trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. TIP47 has been localized in milk fat globule membranes of human and bovine origin. It has been described as a placental protein, as well. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients. Therefore, this protein is probably significant as an oncodevelopmental marker.
Synonyms	M6PRBP1; PP17; TIP47
Reference Data
Protein Families	Druggable Genome

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