MRE11 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ChIP, ELISA, FC, ICC/IF, IHC, Immunoblotting, IP, Simple Western, WB
Recommend Dilution	Chromatin Immunoprecipitation (ChIP), Knockdown Validated, Proximity Ligation Assay, Immunocytochemistry/ Immunofluorescence: 1:200, Immunohistochemistry-Paraffin: 1:10 - 1:500, Immunohistochemistry: 1:10 - 1:500, Simple Western: 1:250, Western Blot: 1:5000, Immunoprecipitation: 3 uL, Flow Cytometry, Immunoblotting, Immunohistochemistry-Frozen, Knockout Validated, ELISA
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length human Mre11 protein
Formulation	Sodium azide
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	MRE11 homolog A, double strand break repair nuclease
Database Link	NP_005582 Entrez Gene 17535 MouseEntrez Gene 4361 Human UniProt ID P49959
Background	The hMre11-hRad50-NBS1 protein plays a central role in the human cellular DNA-Damage response, with recent studies indicating that these proteins help link DNA-damage detection to DNA-repair and cell cycle-checkpoint functions. This protein complex has been implicated in the activation of cell cycle-regulatory pathways, due to the fact that the NBS1 gene mutates in the chromosomal-instability syndrome, Nijmegen breakdown syndrome (NBS), which is characterized by increased cancer incidence, cell cycle checkpoint defects, and ionizing radiation sensitivity.
Synonyms	ATLD; HNGS1; MRE11; MRE11B
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Homologous recombination, Non-homologous end-joining

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