NANOG Rabbit Polyclonal Antibody
CAT#: TA302154
Rabbit Polyclonal Antibody against NANOG (Center)
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CNY 6,314.00
货期*
5周
规格
经常一起买 (2)
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Specifications
Product Data | |
Applications | FC, IF, IHC, WB |
Recommend Dilution | WB: 1:1000, IHC: 1:10~50, IF: 1:10~50, FC: 1:10~50 |
Reactivity | Human, Bovine, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | This NANOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-123 amino acids from the Central region of human NANOG. |
Formulation | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
Concentration | lot specific |
Purification | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 34489 Da |
Gene Name | Nanog homeobox |
Database Link | |
Background | NANOG is a Ttranscription regulator involved in inner cell mass and embryonic stem (ES) cels proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation. |
Synonyms | homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; Nanog homeobox |
Reference Data | |
Protein Families | Cancer stem cells, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Stem cell - Pluripotency |
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