Hsc70 (HSPA8) Goat Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Peptide-ELISA: 1:4,000. WB: 1-3µg/ml. IF: Strong expression of the protein seen in the cytoplasm of HeLa cells. Recommended concentration: 10µg/ml IHC: Paraffin embedded Human Prostate. Recommended concentration: 5µg/ml.
Reactivity	Human, Rat, Dog, Mouse
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-EKLQGKINDEDKQK, from the internal region of the protein sequence according to NP_006588.1.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	70.7 kDa
Gene Name	heat shock protein family A (Hsp70) member 8
Database Link	NP_006588 Entrez Gene 15481 MouseEntrez Gene 24468 RatEntrez Gene 479406 DogEntrez Gene 3312 Human UniProt ID P11142
Background	The product encoded by this gene belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date. [provided by RefSeq]
Synonyms	HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71
Reference Data
Protein Families	Stem cell - Pluripotency
Protein Pathways	Antigen processing and presentation, Endocytosis, MAPK signaling pathway, Spliceosome

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