GAB2 Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:64,000. WB: 0.5-1.5µg/ml.
Reactivity	Human, Mouse, Rat, Dog
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-QVDKEKTQALQN, from the internal region (near the C Terminus) of the protein sequence according to NP_536739.1; NP_036428.1.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	GRB2 associated binding protein 2
Database Link	NP_036428 Entrez Gene 14389 MouseEntrez Gene 84477 RatEntrez Gene 485167 DogEntrez Gene 9846 Human UniProt ID Q9UQC2
Background	This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq]
Synonyms	KIAA0571
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Chronic myeloid leukemia, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis

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