Cathepsin K (CTSK) Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:16,000. WB: 1-3µg/ml.
Reactivity	Human, Mouse, Rat, Dog, Pig, Cow
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-KTHRKQYNNKVDE, from the internal region (near N-terminus) of the protein sequence according to NP_000387.1.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cathepsin K
Database Link	NP_000387 Entrez Gene 13038 MouseEntrez Gene 29175 RatEntrez Gene 608843 DogEntrez Gene 1513 Human UniProt ID P43235
Background	The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq]
Synonyms	CTS02; CTSO; CTSO1; CTSO2; PKND; PYCD
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Lysosome

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