RAMP1 Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.3ug/ml.
Reactivity	Rat, Human, Mouse
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-DYQSKRTEGIV, from the C-Terminus of the protein sequence according to NP_058590.1; NP_848488.2.
Formulation	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	receptor activity modifying protein 1
Database Link	NP_005846 Entrez Gene 51801 MouseEntrez Gene 58965 RatEntrez Gene 10267 Human UniProt ID O60894
Background	The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq]
Synonyms	receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; receptor-activity modifying protein 1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Vascular smooth muscle contraction

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