ALS2 Goat Polyclonal Antibody
CNY 5,371.00
货期*
5周
规格
经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 3-5ug/ml. |
Reactivity | Human, Mouse, Rat, Dog, Cow |
Host | Goat |
Clonality | Polyclonal |
Immunogen | Peptide with sequence LKACYYQIQREKLN, from the C Terminus of the protein sequence according to NP_065970.2. |
Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Concentration | lot specific |
Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | ALS2, alsin Rho guanine nucleotide exchange factor |
Database Link | |
Background | The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Synonyms | ALS2CR6; ALSJ; IAHSP; PLSJ |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Amyotrophic lateral sclerosis (ALS) |
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