Ripk3 Rabbit Polyclonal Antibody

CAT#: TA306042

Rabbit Polyclonal RIP3 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen RIP3 antibody was raised against a 14 amino acid peptide near the carboxy terminus of murine RIP3. The immunogen is located within the last 50 amino acids of RIP3.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Gene Name receptor-interacting serine-threonine kinase 3
Background Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3 (1-3). RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-kappaB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues (2,3).
Synonyms RIP-3; RIP3
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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