PHAP1 (ANP32A) Rabbit Polyclonal Antibody

CAT#: TA306130

Rabbit Polyclonal PHAP I Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

Product images

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Specifications

Product Data
Applications ELISA, IF, IHC, WB
Recommend Dilution WB: 1 µg/mL; IHC: 2 µg/mL; IF: 20 µg/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in mouse samples; Immunofluorescence in mouse samples. All other applications and species not yet tested.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen PHAP I antibody was raised with a synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I.
Specificity This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification PHAP I Antibody is DEAE purified.
Conjugation Unconjugated
Storage Condition Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Gene Name acidic nuclear phosphoprotein 32 family member A
Background Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis (1). PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
Synonyms C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1; PHAPI; PP32
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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