CARD11 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 0.5 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	CARMA1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.
Formulation	PBS containing 0.02% sodium azide.
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase recruitment domain family member 11
Database Link	NP_115791 Entrez Gene 108723 MouseEntrez Gene 84433 Human UniProt ID Q9BXL7
Background	CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules (1). CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types (2-4). Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I?K complex, thereby regulating activation of the NF-kappaB transcription factor (5). Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems (6).
Synonyms	BENTA; BIMP3; CARMA1; IMD11; PPBL
Reference Data
Protein Families	Druggable Genome
Protein Pathways	B cell receptor signaling pathway, T cell receptor signaling pathway

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