Casp12 Rabbit Polyclonal Antibody

CAT#: TA306140

Rabbit Polyclonal Caspase-12 Antibody (Large)



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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经常一起买 (2)
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Transient overexpression lysate of caspase 12 (gene/pseudogene) (CASP12), transcript variant 1
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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 10 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Caspase-12 antibody was raised against a synthetic peptide corresponding to amino acids within the large cleavage product of murine caspase-12.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name caspase 12
Background Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved (1,2). Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including ?-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues (1).
Synonyms CASP-12; CASP12P1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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