MAP2K1IP1 (LAMTOR3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB:1:500-1:3000
Reactivity	Human, Mouse, Bovine, X. tropicalis
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 1 and 124 of MP1 (Uniprot ID#Q9UHA4)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	14 kDa
Gene Name	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Database Link	NP_068805 Entrez Gene 56692 MouseEntrez Gene 8649 Human UniProt ID Q9UHA4
Background	This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Multiple transcript variants are expressed by this gene, but only one variant is thought to express a protein. [provided by RefSeq]
Synonyms	MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; Ragulator3
Note	Seq homology of immunogen across species: Mouse (97%), Bovine (99%), Xenopus tropicalis (85%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	MAPK signaling pathway

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