KPNA2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	ICC/IF:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Rat, Chimpanzee, Rhesus Monkey, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region within amino acids 468 and 529 of KPNA2 (Uniprot ID#P52292)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	58 kDa
Gene Name	karyopherin subunit alpha 2
Database Link	NP_002257 Entrez Gene 16647 MouseEntrez Gene 85245 RatEntrez Gene 3838 Human UniProt ID P52292
Background	The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq]
Synonyms	IPOA1; QIP2; RCH1; SRP1-alpha; SRP1alpha
Note	Seq homology of immunogen across species: Mouse (100%), Rat (100%), Rhesus Monkey (92%), Chimpanzee (100%)
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency

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