Fatty Acid Synthase (FASN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Mouse, Rat, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 401 and 694 of Fatty Acid Synthase (Uniprot ID#P49327)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	273 kDa
Gene Name	fatty acid synthase
Database Link	NP_004095 Entrez Gene 14104 MouseEntrez Gene 50671 RatEntrez Gene 2194 Human UniProt ID P49327
Background	The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq]
Synonyms	FAS; OA-519; SDR27X1
Note	Seq homology of immunogen across species: Rat (85%), Bovine (81%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Fatty acid biosynthesis, Insulin signaling pathway, Metabolic pathways

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