RASSF1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	ICC/IF:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 50 and 344 of RASSF1 (Uniprot ID#Q9NS23)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	39 kDa
Gene Name	Ras association domain family member 1
Database Link	NP_733832 Entrez Gene 56289 MouseEntrez Gene 363140 RatEntrez Gene 11186 Human UniProt ID Q9NS23
Background	This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
Synonyms	123F2; NORE2A; RASSF1A; RDA32; REH3P21
Note	Seq homology of immunogen across species: Mouse (91%), Rat (91%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Bladder cancer, Non-small cell lung cancer, Pathways in cancer

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