CIITA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:5,000 - 1:25,000, WB: 1:500 - 1:3,000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen used for this study was a bacterially produced recombinant FLAG-CIITA corresponding to amino acids 1 through 333 of the human protein.
Formulation	None
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	class II, major histocompatibility complex, transactivator
Database Link	NP_000237 Entrez Gene 4261 Human UniProt ID P33076
Synonyms	C2TA; CIITAIV; MHC2TA; NLRA
Note	Anti-CIITA antibody detects CIITA. The transactivator CIITA regulates basal and interferon-induced expression of Major Histocompatibility Complex class II genes. CIITA restores expression of all MHC class II gene expression in mutant cells and corrects regulatory defects of MHC class II genes. Antibodies to this transactivator are useful in the study of diseases of pathological MHC class II expression. Antigen can be obtained from Raji cell lysates. Typically levels of CIITA expression are too low to detect endogenous levels of protein expression. Transiently transfected cells are usually employed to study this transcription factor.
Reference Data
Protein Pathways	Antigen processing and presentation, Primary immunodeficiency

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