Hif3a Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:14,000 - 1:80,000, WB: 1:1,000 - 1:8,000
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to aa 581-592 of mouse Hif3 a (Hypoxia Inducible Factor).
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	hypoxia inducible factor 3, alpha subunit
Database Link	NP_058564 Entrez Gene 53417 Mouse UniProt ID Q0VBL6
Synonyms	bHLHe17; HIF-3A; HIF-3A2; HIF-3A4; IPAS; MOP7; PASD7
Note	One of the most important factors in the cellular response to hypoxia is hypoxia-inducible factor (HIF), which transcriptionally activates genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three PRIVATE ''TYPE=PICT;ALT={alpha}''subunits (HIF1-aPRIVATE ''TYPE=PICT;ALT={alpha}'', HIF2-a,PRIVATE ''TYPE=PICT;ALT={alpha}'' or HIF3-a)PRIVATE ''TYPE=PICT;ALT={alpha}'' bound to the aryl hydrocarbon receptor nuclear translocator (ARNT) that is also known as HIF1-b. HIF-aPRIVATE ''TYPE=PICT;ALT={alpha}'' is a member of the basic helix-loop-helix (bHLH) superfamily, in which the HLH domain mediates subunit dimerization while the basic domain binds to DNA. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation, and cell survival; in fact, HIF3-a may be a marker for tumor growth and angiogenesis . Examples of HIF target genes include VEGF, glucose transporter 1 (GLUT1), and EPO. HIF binds to the hypoxia-responsive
Reference Data

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