PDCD4 Rabbit Polyclonal Antibody

CAT#: TA319401

Rabbit polyclonal Pdcd4 phospho S457 antibody (Phospho-specific)



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CNY 8,025.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution ELISA: 1:400,000, WB: 1:500 - 1:2,000, IHC: 21.25 - 2.5 ug/ml
Reactivity Human, Mouse, Xenopus, Rat
Modifications Phospho-specific
Host Rabbit
Clonality Polyclonal
Immunogen This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids surrounding Ser457 in the human Pdcd4 protein.
Formulation 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration lot specific
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name programmed cell death 4 (neoplastic transformation inhibitor)
Synonyms H731
Note This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphorylation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.
Reference Data
Protein Families Druggable Genome
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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