TIMP4 Mouse Monoclonal Antibody [Clone ID: 9:4-7]

Specifications

Product Data
Clone Name	9:4-7
Applications	IHC
Recommend Dilution	ELISA: 1:20,000 to 1:100,000, WB: 1:2,000 to 1:10,000, IHC: 5-10ug/mL
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Anti-TIMP4 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with full legnth human TIMP4 protein followed by hybridoma development.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TIMP metallopeptidase inhibitor 4
Database Link	NP_003247 Entrez Gene 110595 MouseEntrez Gene 7079 Human UniProt ID Q99727
Synonyms	TIMP metallopeptidase inhibitor 4; tissue inhibitor of metalloproteinase 4
Note	Tissue inhibitor of metalloproteinase-4 (TIMP-4) is member of the TIMP family of inhibitors of matrix metalloproteinase (MMP) activities. In addition, TIMPs have non-MMP associated functions, including roles in growth promotion, apoptosis, and angiogenesis. All four members of the TIMP gene family form a similar secondary structure due to the formation of six highly conserved disulfide bonds. It has been reported that some TIMPs, TIMP4 included, can bind a tetraspanin in the plasma membrane, initiating an intra-cellular signaling cascade. Elevated levels of TIMP4 have been associated with breast cancer progression and heart disease.
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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