APAF1 Mouse Monoclonal Antibody [Clone ID: 2E10]

Specifications

Product Data
Clone Name	2E10
Applications	IHC, WB
Recommend Dilution	ICC: 0.5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	A peptide corresponding to amino acids near the carboxy terminus of human Apaf1.
Formulation	Apaf-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Apaf-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	130 kDa
Gene Name	apoptotic peptidase activating factor 1
Database Link	AAC51678 Entrez Gene 317 Human UniProt ID O14727
Background	Apaf-1 Monoclonal Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologous of the key cell death gene CED-4 in C. elegans was identified recently from human and mouse and designated Apaf1 for apoptosis protease-activating factor 1. Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 transcript is ubiquitously expressed in human tissues.
Synonyms	APAF-1; CED4
Reference Data

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