FOXO1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, ICC:4 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	FOXO1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human FOXO1.
Formulation	FOXO1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	FOXO1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Gene Name	forkhead box O1
Database Link	NP_002006 Entrez Gene 56458 MouseEntrez Gene 84482 RatEntrez Gene 2308 Human UniProt ID Q12778
Background	FOXO1 Antibody: FOXO1, also known as FKHR or ForkHead in Rhabdomyosarcoma, is a 70 kDa protein which is a ubiquitously expressed member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In insulin-responsive tissues, stress or nutrient abundance triggers phosphorylation by PKB/AKT, blocking nuclear translocation and activity. Genetic mutations involving FOXO1A are a cause of alveolar rhabdomyosarcoma (RMS2). Recent studies link the anti-tumor activity of FOXO1 and the process of autophagy.
Synonyms	FKH1; FKHR; FOXO1A
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Insulin signaling pathway, Pathways in cancer, Prostate cancer

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.