Nephrin (NPHS1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Nephrin antibody was raised against a 16 amino acid synthetic peptide from near the center of human Nephrin.
Formulation	Nephrin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Nephrin Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NPHS1 nephrin
Database Link	NP_004637 Entrez Gene 4868 Human UniProt ID O60500
Background	Nephrin Antibody: Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm.
Synonyms	CNF; nephrin; NPHN
Reference Data
Protein Families	Druggable Genome, Transmembrane

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