XBP1 Mouse Monoclonal Antibody [Clone ID: 3H1G4]

Specifications

Product Data
Clone Name	3H1G4
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2 ug/mL, IF: 4 ug/mL
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Mouse monoclonal XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to 160 of human XBP-1.
Formulation	XBP-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	XBP-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	X-box binding protein 1
Database Link	BAB82982 Entrez Gene 7494 Human UniProt ID P17861
Background	XBP-1 Monoclonal Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.
Synonyms	TREB-5; TREB5; XBP-1; XBP2
Reference Data

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