NUMB Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 0.25 - 0.5 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	NUMB antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human NUMB.
Formulation	NUMB Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	NUMB Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NUMB, endocytic adaptor protein
Database Link	NP_001005743 Entrez Gene 18222 MouseEntrez Gene 29419 RatEntrez Gene 8650 Human UniProt ID P49757
Background	NUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.
Synonyms	C14orf41; c14_5527; S171
Reference Data
Protein Pathways	Notch signaling pathway

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