Bcl2 Binding component 3 (BBC3) Mouse Monoclonal Antibody [Clone ID: 2A8F6]

Specifications

Product Data
Clone Name	2A8F6
Applications	WB
Recommend Dilution	WB: 2.5 - 5 ug/mL
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
Formulation	PUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	BCL2 binding component 3
Database Link	NP_001120712 Entrez Gene 317673 RatEntrez Gene 27113 Human UniProt ID Q9BXH1
Background	PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Synonyms	JFY-1; JFY1; PUMA
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Huntington's disease, p53 signaling pathway

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