SLC39A1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	ZIP1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human ZIP1.
Formulation	ZIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	ZIP1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	solute carrier family 39 member 1
Database Link	NP_055252 Entrez Gene 30791 MouseEntrez Gene 27173 Human UniProt ID Q9NY26
Background	ZIP1 Antibody: ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
Synonyms	ZIP1; ZIRTL
Reference Data
Protein Families	Transmembrane

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