ZBTB4 Rabbit Polyclonal Antibody
CNY 5,808.00
货期*
4周
规格
经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | ZBTB4 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZBTB4. |
Formulation | ZBTB4 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | ZBTB4 Antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | zinc finger and BTB domain containing 4 |
Database Link | |
Background | ZBTB4 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage. |
Synonyms | KAISO-L1; ZNF903 |
Reference Data |
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