ZBTB4 Rabbit Polyclonal Antibody

CAT#: TA319989

Rabbit Polyclonal ZBTB4 Antibody



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CNY 5,808.00


货期*
4周

规格
    • 100 ug

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经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen ZBTB4 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZBTB4.
Formulation ZBTB4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification ZBTB4 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name zinc finger and BTB domain containing 4
Background ZBTB4 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.
Synonyms KAISO-L1; ZNF903
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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