DISP2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	DISP2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DISP2.
Formulation	DISP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	DISP2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	dispatched RND transporter family member 2
Database Link	NP_277045 Entrez Gene 85455 Human UniProt ID A7MBM2
Background	DISP2 Antibody: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.
Synonyms	DISPB; HsT16908
Reference Data
Protein Families	Transmembrane

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