TORC2 (CRTC2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CRTC2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRTC2.
Formulation	CRTC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CRTC2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 67, 76 kDa; Observed: 70 kDa
Gene Name	CREB regulated transcription coactivator 2
Database Link	NP_859066 Entrez Gene 74343 MouseEntrez Gene 310615 RatEntrez Gene 200186 Human UniProt ID Q53ET0
Background	CRTC2 Antibody: CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.
Synonyms	TORC-2; TORC2
Reference Data

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