SPO11 Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1-3µg/ml
Reactivity	Human, Mouse
Host	Goat
Clonality	Polyclonal
Immunogen	internal region of NP_036576.1; NP_937998.1 (NTYATKRDIYYTDSQ)
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	SPO11, initiator of meiotic double stranded breaks
Database Link	NP_036576 Entrez Gene 26972 MouseEntrez Gene 23626 Human UniProt ID Q9Y5K1
Background	Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]
Synonyms	CT35; SPATA43; TOPVIA
Note	This antibody is expected to recognize both reported isoforms (NP_036576.1; NP_937998.1)
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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