Alkaline Phosphatase (ALPL) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 200-400 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 2-329amino acids of Human Alkaline phosphatase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	alkaline phosphatase, liver/bone/kidney
Database Link	NP_000469 Entrez Gene 11647 MouseEntrez Gene 25586 RatEntrez Gene 249 Human UniProt ID P05186
Background	There are at least four distinct but related alkaline phosphatases: intestinal; placental; placental-like; and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2; while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is; therefore; referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however; mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia; a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary; however; depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
Synonyms	AP-TNAP; APTNAP; HOPS; TNAP; TNSALP
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Folate biosynthesis, Metabolic pathways

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