5 Lipoxygenase (ALOX5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-150 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to N terminal 359 amino acids of Human Arachidonate 5-lipoxygenase Arachidonate 5-lipoxygenase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	arachidonate 5-lipoxygenase
Database Link	NP_000689 Entrez Gene 11689 MouseEntrez Gene 25290 RatEntrez Gene 240 Human UniProt ID P09917
Background	This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein; which is expressed specifically in bone marrow-derived cells; catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8;11;14-cis-eicosatetraenoic acid; and further to the allylic epoxide 5(S)-trans-7;9-trans-11;14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	5-LO; 5-LOX; 5LPG; LOG5
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arachidonic acid metabolism, Metabolic pathways

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