DUSP4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: RAW264.7 cells IHC: 50-150 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm, Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 197-394 amino acids of human dual specificity phosphatase 4
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	43 kDa
Gene Name	dual specificity phosphatase 4
Database Link	NP_001385 Entrez Gene 60587 RatEntrez Gene 319520 MouseEntrez Gene 1846 Human UniProt ID Q13115
Background	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK; SAPK/JNK; p38); which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases; different tissue distribution and subcellular localization; and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1; ERK2 and JNK; is expressed in a variety of tissues; and is localized in the nucleus. Two alternatively spliced transcript variants; encoding distinct isoforms; have been observed for this gene. In addition; multiple polyadenylation sites have been reported.
Synonyms	HVH2; MKP-2; MKP2; TYP
Reference Data
Protein Families	Phosphatase
Protein Pathways	MAPK signaling pathway

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