PARP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Jurkat and Hela cells IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 12-21 amino acids of human poly (ADP-ribose) polymerase 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	113 kDa
Gene Name	poly(ADP-ribose) polymerase 1
Database Link	NP_001609 Entrez Gene 11545 MouseEntrez Gene 25591 RatEntrez Gene 142 Human UniProt ID P09874
Background	This gene encodes a chromatin-associated enzyme; poly(ADP-ribosyl)transferase; which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation; proliferation; and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition; this enzyme may be the site of mutation in Fanconi anemia; and may participate in the pathophysiology of type I diabetes.
Synonyms	ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Base excision repair

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