NGF Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela cell lysate IHC: 50-100 Positive control: Human tonsil Predicted cell location: Secreted
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 80-94 amino acids of human nerve growth factor (beta polypeptide)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	27 kDa
Gene Name	nerve growth factor
Database Link	NP_002497 Entrez Gene 18049 MouseEntrez Gene 310738 RatEntrez Gene 4803 Human UniProt ID P01138
Background	This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy; type 5 (HSAN5); and dysregulation of this gene's expression is associated with allergic rhinitis.
Synonyms	Beta-NGF; HSAN5; NGFB
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Apoptosis, MAPK signaling pathway, Neurotrophin signaling pathway

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