PDK4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Rat heart tissue lysate
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 101-113 amino acids of Human pyruvate dehydrogenase kinase, isozyme 4
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46 kDa
Gene Name	pyruvate dehydrogenase kinase 4
Database Link	NP_002603 Entrez Gene 27273 MouseEntrez Gene 89813 RatEntrez Gene 5166 Human UniProt ID Q16654
Background	This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits; thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids; retinoic acid and insulin.
Synonyms	FLJ40832
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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