Pleiotrophin (PTN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Human colon cancer tissue
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 33-47 amino acids of human pleiotrophin
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	19 kDa
Gene Name	pleiotrophin
Database Link	NP_002816 Entrez Gene 19242 MouseEntrez Gene 24924 RatEntrez Gene 5764 Human UniProt ID P21246
Background	Pleiotrophin?(PTN) also known as?heparin-binding brain mitogen?(HBBM) or?heparin-binding growth factor 8?(HBGF-8) or?neurite growth-promoting factor 1?(NEGF1) or?heparin affinity regulatory peptide?(HARP) or?heparin binding growth associated molecule?(HB-GAM) is a?protein?that in humans is encoded by the?PTNgene.?Pleiotrophin is an 18-kDa?growth factor?that has a high affinity for?heparin. It is structurally related to?midkine?and?retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts; epithelial; and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation; an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Synonyms	HARP; HBGF8; HBNF; NEGF1
Reference Data
Protein Families	Druggable Genome, Phosphatase, Secreted Protein, Transmembrane

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