GJB2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 100-300 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm, Cell membrane
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 212-227 amino acids of Human gap junction protein, beta 2, 26kDa
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	gap junction protein beta 2
Database Link	NP_003995 Entrez Gene 394266 RatEntrez Gene 2706 Human UniProt ID P29033
Background	This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins; also known as connexins; purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels; the gap junction proteins are divided into two categories; alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual; recessive deafness.
Synonyms	CX26; DFNA3; DFNA3A; DFNB1; DFNB1A; HID; KID; NSRD1; PPK
Reference Data
Protein Families	Druggable Genome, Ion Channels: Other, Transmembrane

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