p27 KIP 1 (CDKN1B) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Jurkat and Raji cell lysates IHC: 50-100 Positive control: Human prostate cancer Predicted cell location: Cytoplasm and Nucleus
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	22 kDa
Gene Name	cyclin-dependent kinase inhibitor 1B
Database Link	NP_004055 Entrez Gene 12576 MouseEntrez Gene 1027 Human UniProt ID P46527
Background	This gene encodes a cyclin-dependent kinase inhibitor; which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes; and thus controls the cell cycle progression at G1. The degradation of this protein; which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes; is required for the cellular transition from quiescence to the proliferative state.
Synonyms	CDKN4; KIP1; MEN1B; MEN4; P27KIP1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, Chronic myeloid leukemia, ErbB signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer

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