DAP12 (TYROBP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 28-40 amino acids of Human TYRO protein tyrosine kinase binding protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TYRO protein tyrosine kinase binding protein
Database Link	NP_937758 Entrez Gene 22177 MouseEntrez Gene 361537 RatEntrez Gene 7305 Human UniProt ID O43914
Background	This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction; bone modeling; brain myelination; and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as Nasu-Hakola disease. Its putative receptor; triggering receptor expressed on myeloid cells 2 (TREM2); also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms	DAP12; KARAP; PLOSL
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Natural killer cell mediated cytotoxicity

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