DTX3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: Human lymphoma tissue
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 248 amino acids of human deltex homolog 3 (Drosophila)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	38 kDa
Gene Name	deltex 3, E3 ubiquitin ligase
Database Link	NP_848597 Entrez Gene 80904 MouseEntrez Gene 196403 Human UniProt ID Q8N9I9
Background	DTX3 functions as an E3 ubiquitin ligase. Regulator of Notch signaling; a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch; depending on the developmental and cell context By similarity. Functions as an ubiquitin ligase protein in vitro; suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Synonyms	deltex3; RNF154
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Notch signaling pathway

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