HMGB4 Rabbit Polyclonal Antibody

CAT#: TA322036

Anti-HMGB4 Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ul

Product images

经常一起买 (2)
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Specifications

Product Data
Applications WB
Recommend Dilution WB: 200-1000
WB positive control: 231 cells and human fetal liver tissue
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Full length fusion protein
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 22 kDa
Gene Name high mobility group box 4
Background High mobility group protein B4?is a?transcription factor?that in humans is encoded by the?HMGB4?gene.HMGB4 is strongly and preferentially expressed in the adult mouse testis and weakly in the brain; but not in many other tissues. HMGB4 associates with chromatin; and in transfection assays; in contrast to HMGB1; it acts as a potent transcriptional repressor. During spermatogenesis; HMGB4 is present in the euchromatin of late pachytene spermatocytes and haploid round spermatids; whereas stronger expression is observed during the elongation phase; where it localizes to the basal pole of the nucleus in a manner mutually exclusive with H1FNT (H1T2) localized at the apical pole. HMGB4 basal localization is lost in H1FNT-mutant spermatids; showing that H1FNT provides a positional cue for organizing chromatin domains within the nucleus. These results show that HMGB4 and H1FNT specify distinct chromatin domains at the apical and basal poles of the elongating spermatid nucleus.
Synonyms dJ1007G16.5
Reference Data
Protein Families Transcription Factors
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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